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Soffietti R, Pellerino A, Bruno F, Mauro A, Ruda R

At the molecular levels, our data showed that the protective effect of DHEA is mediated by stimulating Bcl-2 levels and upregulation/activation of SIRT1 signaling, including deacetylation of Nrf2, NF-B p65, p53, and FOXO3a

Elevated ROS levels can oxidatively modify mitochondrial lipids and proteins, resulting in functional disruption of the electron transport chain (ETC.) and increased permeability of the mitochondrial membrane